| 09/10/2010 | Cerrito | 4 | vs. | 0 | Juventud |
| 09/10/2010 | Rocha F.C. | 2 | vs. | 0 | Cerro Largo |
| 09/10/2010 | Deportivo Maldonado | 0 | vs. | 1 | A.A. Durazno F.C. |
| 09/10/2010 | Plaza Colonia | 1 | vs. | 3 | Rentistas |
| 09/10/2010 | Sud América | 3 | vs. | 1 | Huracán |
| 10/10/2010 | Atenas | 2 | vs. | 0 | Boston River |
|
| Segunda Fecha |
| 16/10/2010 | Boston River | 0 | vs. | 2 | Cerro Largo |
| 16/10/2010 | Huracán | 1 | vs. | 1 | Cerrito |
| 16/10/2010 | Deportivo Maldonado | 1 | vs. | 1 | Rentistas |
| 16/10/2010 | A.A. Durazno F.C. | 1 | vs. | 0 | Plaza Colonia |
| 16/10/2010 | Juventud | 2 | vs. | 2 | Sud América |
| 16/10/2010 | Rocha F.C. | 0 | vs. | 1 | Atenas |
|
| Tercera Fecha |
| 23/10/2010 | Cerrito | 1 | vs. | 1 | Rentistas |
| 23/10/2010 | Cerro Largo | 3 | vs. | 0 | A.A. Durazno F.C. |
| 23/10/2010 | Boston River | 1 | vs. | 1 | Deportivo Maldonado |
| 23/10/2010 | Plaza Colonia | 3 | vs. | 1 | Huracán |
| 24/10/2010 | Atenas | 3 | vs. | 1 | Sud América |
| 23/10/2010 | Juventud | 2 | vs. | 0 | Rocha F.C. |
|
| Cuarta Fecha |
| 30/10/2010 | Plaza Colonia | 1 | vs. | 1 | Cerro Largo |
| 30/10/2010 | Deportivo Maldonado | 1 | vs. | 0 | Cerrito |
| 30/10/2010 | Rentistas | 0 | vs. | 2 | Huracán |
| 30/10/2010 | A.A. Durazno F.C. | 0 | vs. | 4 | Boston River |
| 30/10/2010 | Atenas | 1 | vs. | 0 | Juventud |
| 30/10/2010 | Sud América | 0 | vs. | 2 | Rocha F.C. |
|
| Quinta Fecha |
| 07/11/2010 | Cerrito | 4 | vs. | 1 | Sud América |
| 06/11/2010 | Cerro Largo | 4 | vs. | 2 | Atenas |
| 06/11/2010 | Boston River | 2 | vs. | 1 | Rentistas |
| 06/11/2010 | Huracán | 1 | vs. | 1 | A.A. Durazno F.C. |
| 06/11/2010 | Deportivo Maldonado | 1 | vs. | 1 | Juventud |
| 06/11/2010 | Rocha F.C. | 1 | vs. | 0 | Plaza Colonia |
|
| Sexta Fecha |
| 13/11/2010 | Juventud | 0 | vs. | 1 | Cerro Largo |
| 13/11/2010 | Rocha F.C. | 0 | vs. | 2 | Cerrito |
| 13/11/2010 | A.A. Durazno F.C. | 0 | vs. | 1 | Rentistas |
| 13/11/2010 | Huracán | 1 | vs. | 2 | Boston River |
| 13/11/2010 | Sud América | 0 | vs. | 0 | Deportivo Maldonado |
| 13/11/2010 | Plaza Colonia | 1 | vs. | 0 | Atenas |
|
| Séptima Fecha |
| 20/11/2010 | Cerro Largo | 0 | vs. | 0 | Huracán |
| 20/11/2010 | Boston River | 1 | vs. | 1 | Cerrito |
| 21/11/2010 | Atenas | 3 | vs. | 0 | A.A. Durazno F.C. |
| 20/11/2010 | Rentistas | 1 | vs. | 0 | Sud América |
| 20/11/2010 | Deportivo Maldonado | 1 | vs. | 1 | Rocha F.C. |
| 20/11/2010 | Juventud | 2 | vs. | 0 | Plaza Colonia |
|
| Octava Fecha |
| 27/11/2010 | Cerrito | 4 | vs. | 0 | A.A. Durazno F.C. |
| 27/11/2010 | Cerro Largo | 0 | vs. | 4 | Rentistas |
| 28/11/2010 | Rocha F.C. | 0 | vs. | 0 | Boston River |
| 27/11/2010 | Huracán | 0 | vs. | 1 | Juventud |
| 28/11/2010 | Deportivo Maldonado | 0 | vs. | 2 | Atenas |
| 27/11/2010 | Sud América | 2 | vs. | 1 | Plaza Colonia |
|
| Novena Fecha |
| 04/12/2010 | Cerrito | 1 | vs. | 1 | Cerro Largo |
| 04/12/2010 | A.A. Durazno F.C. | 2 | vs. | 0 | Rocha F.C. |
| 04/12/2010 | Rentistas | 2 | vs. | 0 | Juventud |
| 04/12/2010 | Plaza Colonia | 1 | vs. | 2 | Deportivo Maldonado |
| 04/12/2010 | Atenas | 3 | vs. | 0 | Huracán |
| 04/12/2010 | Boston River | 5 | vs. | 3 | Sud América |
|
| Décima Fecha |
| 11/12/2010 | Atenas | 2 | vs. | 4 | Cerrito |
| 11/12/2010 | Sud América | 0 | vs. | 2 | Cerro Largo |
| 11/12/2010 | Boston River | 1 | vs. | 0 | Plaza Colonia |
| 11/12/2010 | Rocha F.C. | 1 | vs. | 1 | Rentistas |
| 11/12/2010 | Juventud | 0 | vs. | 2 | A.A. Durazno F.C. |
| 11/12/2010 | Deportivo Maldonado | 1 | vs. | 0 | Huracán |
|
| Undécima Fecha |
| 18/12/2010 | Cerro Largo | 0 | vs. | 0 | Deportivo Maldonado |
| 18/12/2010 | Cerrito | 2 | vs. | 1 | Plaza Colonia |
| 18/12/2010 | A.A. Durazno F.C. | 2 | vs. | 2 | Sud América |
| 18/12/2010 | Rentistas | 1 | vs. | 1 | Atenas |
| 18/12/2010 | Juventud | 1 | vs. | 2 | Boston River |
| 18/12/2010 | Huracán | 1 | vs. | 2 | Rocha F.C. |
